MMaria,
Do you mean fig 67 on the AD8295 data sheet?
You may want to play around with ADIdiffAmpCalc: http://www.analog.com/en/amplifier-linear-tools/adi-diff-amp-calc/topic.html
Also: http://designtools.analog.com/dt/stability/stability.html
Also: http://designtools.analog.com/dt/opamp/opamp.html
YOu can download an ADI version of Multisim for free:
http://www.analog.com/en/amplifier-linear-tools/multisim/topic.html
So sometimes it's best to take a simple circuit and change one thing at at time and figure out why it works.
I'm not clear what you question is.
If you have two signals, V1 and V2, and V1 is at 3V and V2 is at 2V, then (V1 - V2) = +1V.
If I reverse the voltages, so V1 = 2V, and V3 = 3V, then V1 - V2 = -1V.
So you can have a differential signal that is plus or minus, even though both of the inputs to the InAmp
or the ADC are both positive.
Harry