AD8220 Ref. Voltage

Hi,

I am using AD8220 to amplify the output voltage of a Wheatstone bridge (there is only an NTC Thermistor in the bridge).

I want to use the InAmp in single supply operation. The bridge is designed to always provide the positive input voltage to the InAmp

(Vin= (Vin+) - (Vin-) > 0 ).

The question is if it is necessary to connect the REF pin to Vsupply/2 in this case or it can be tied to GND.

Thanks for your help.